A burden of kidney diseases is much high than commonly reported, as per the notice issued by European Renal Association—European Dialysis and Transplant Association (ERA-EDTA), American Society of Nephrology, and International Society of Nephrology. The groups also stated that more than 850 million people globally suffer from some kind of kidney disease, which is double the number of people having diabetes, and 20 times more than the prevalence of cancer globally. All three organizations are collaborating to improve the prevention efforts for kidney diseases and raising awareness.
According to some experts from organizations, more than 13 million people suffer from acute kidney injury, among these, some of them develop chronic kidney disease while some suffer from kidney failure.
According to the latest study, increase in the number of people suffering from renal failure and rise in diabetic population is likely to result in the growth of the analgesic nephropathy occurring due to the immoderate use of OTC analgesic drugs such as ibuprofen and aspirin.
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Despite the large availability of the observational evidence, the contribution of the specific drug in development of analgesic nephropathy is still undetermined, trials are also lacking and research has so far relied on the epidemiological human studies or animal models with some conflicting outcomes. Moreover, the true prevalence of analgesic nephropathy is difficult to estimate due to the absence of definitive diagnoses.
Currently, the available medication for analgesic nephropathy is either opioids or antiepileptic medication. Meanwhile, experts have found that there are many causes that can go unnoticed and result in kidney damage. Among various causes, the most common are high blood pressure and diabetes followed by inflammation of kidneys. According to the National Institute of Health, long term use of medication like aspirin, acetaminophen and NSAIDs can lead to analgesic nephropathy.
The study has also found that in the modern medicines, paracetamol is one of the widely consumed drugs that can result in the development of analgesic nephropathy. Numerous research studies have also associated regular consumption of paracetamol with increased risk of renal impairment.
According to the latest study, in terms of medication ibuprofen, aspirin, naproxen sodium, and acetaminophen can lead to the increasing risk of analgesic nephropathy. In recent years, owing to the chronic pain and aches among the aging population is resulting in the increasing consumption OTC analgesics and pain management medications, thereby, accelerating the growth of analgesic nephropathy globally.
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The non-medical use and abuse of the prescription drugs are emerging as the serious health issue in North America. According to the National Institute of Drug Abuse, over 200 million opioid prescription drugs were dispensed by retail pharmacies in the US. Hence, the rise in prescription drug abuse in the region is likely to drive the analgesic nephropathy. As per the study, Asia Pacific is also likely to witness significant growth in analgesic nephropathy due to the rise in a number of people suffering from chronic pain problems. Meanwhile, low adoption of pain management medication in the Middle East and Africa is leading to the slow growth of analgesic nephropathy in this region.